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CASE REPORT<
Year : 2014  |  Volume : 2  |  Issue : 2  |  Page : 116

Gastrointestinal stromal tumors (GISTs) - IHC study and correlation of CD-117 and PDGFR-α staining intensity with histomorphological features - A study of 8 cases


1 Professor, Gandhi Medical College, Secundarabad, India
2 Assistant Professor, Principal (Retd) Rangaraya Medical College, Kakinada, India
3 Associate Professor, Principal (Retd) Rangaraya Medical College, Kakinada, India
4 Principal (Retd) Rangaraya Medical College, Kakinada, India

Correspondence Address:
L Krishna
Profesor of pathology, Gandhi Medical College, Secunderabad, 500 003
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-7006.302688

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Gastrointestinal Stromal Tumors (GISTs) are rare and constitute only 1% of all malignant tumors of the Gl Tract but are the most common mesenchymal neoplasm of the Gl tract. GISTS are typically defined by the expression of C-KIT (CD-I 17) in the tumor cells. Here we report a total number of 8 cases of GISTs studied by Immuno histochemical markers. Panel of IHC markers used are CD-117, PDGFR-a,S- 100, Desmin, CD-34, SMA and Epithelial Keratins. CD-117 and PDGFR-a staining intensity correlated with histomorphological features. Risk of progressive disease assessed based on histomorphological features and location of the tumor.


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