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CASE REPORT
Year : 2015  |  Volume : 3  |  Issue : 1  |  Page : 84-86

Cd1a negative langerhans cell histiocytosis: A case report


1 Assistant Professor, Kamineni Academy of Medical Sciences and Research Centre, LB nagar, Hyderabad, India
2 Associate Professor, Kamineni Academy of Medical Sciences and Research Centre, LB nagar, Hyderabad, India
3 Prof and HOD, Department of Pathology, Kamineni Academy of Medical Sciences and Research Centre, LB nagar, Hyderabad, India
4 Department of Neurosurgery, Kamineni Academy of Medical Sciences and Research Centre, LB nagar, Hyderabad, India

Correspondence Address:
Padmaja Korti
W/o Dr Prasanna Belgundi, # 305, Leelam Residency, Opp. Shalini Hospital, Barkatpura, Hyderabad
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-7006.301970

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Langerhans cell histiocytosis (LCH) is a rare histiocytic tumour in adult. We report a case of LCH involving skull bones in a 35year old lady who presented with fever, headache and diabetes insipidus since two years. Radiological examination revealed osteolytic lesions in the parietal and occipital bones along with a solid, enhancing lesion in the pituitary infundibulum. Osteolytic lesions showed ttypical histomorphology of LCH on light microscopy and on IHC it was positive for SI 00 but negative for CD1 a. LCH with CD1 a negativity is very rare and hence we are presenting this case.


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