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ORIGINAL ARTICLE
Year : 2015  |  Volume : 3  |  Issue : 3  |  Page : 164-167

Role of alpha 1 AT, alpha 2 MG among COPD patients


1 Professor and HOD, Department of Pulmonary Medicine, Jubilee Mission Medical College, Thrissur, Kerala, India
2 Professor and HOD, Department of Pulmonary Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, Telangana, India

Correspondence Address:
Supriya Adiody
Professor and HOD, Department of Pulmonary Medicine, Jubilee Mission Medical College, Thrissur, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-7006.302226

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Background: Many biologic processes require a balance between the proteases that initiate the proteolytic pathway essential to life and inhibitors that limit excessive protease activity. Amongst protease inhibitors, serpins appears to control the key intracellular, extracellular pathway. Objective: The study was conducted with an aim to show a relationship between the concentration and activity of protease inhibitors, level of antioxidants (Vitamin C, Vitamin E, and reduced glutathione) and development of obstruction airway disease and bronchiectasis. Methods: A hospital based cross sectional study was carried out among smokers and non smokers. Institutional Ethics committee permission was obtained prior the study. Informed consent was obtained from each and every study and control group patients. The study was conducted over a period of one year. The study included 56 patients in study group out of which emphysema 9 patients, COPD 12 patients, bronchiectasis 14 patients, and bronchial asthma 21 patients. Control group included 25 patients with no respiratory complaints and normal PFT. All patients who satisfied inclusion criteria are included in the study. Results: Our study shows that there is no relationship between the concentration and activity of alpha 1 AT with pulmonary function test. There is no difference between the concentration of alpha 1 AT among smokers and nonsmokers. Alpha 2 MG levels were increased in all pulmonary diseases that we had studied as compared with the normal control group. Levels of Vitamin C are decreased in severe airway obstruction as compared with individuals showing normal pulmonary function test and also are lower in patients with bronchiectasis, COPD, emphysema. Levels of Vitamin E are lower in individuals with mild, moderate and severe airway obstruction as compared with individuals showing normal pulmonary function test, though it is not statistically important. Conclusion: There is an increase in the concentration of reduced glutathione among patients of study group as compared with the normal control group.


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