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ORIGINAL ARTICLE
Year : 2016  |  Volume : 4  |  Issue : 3  |  Page : 138-141

Screening of newly synthesized benzofuran [3-2, d] pyrimidine derivatives for anti inflammatory activity


1 Professor, Department of Pharmacology, Malla Reddy Institute of Medical Sciences, Suraram, Hyderabad, Telangana, India
2 Professor, Department of Pharmacology, S.N. Medical College, Bagalkot, Karnataka, India

Correspondence Address:
Somnath Motgi
Professor, Department of Pharmacology, Malla Reddy Institute of Medical Sciences, Suraram, Hyderabad, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-7006.302261

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Background: Most of the non steroidal anti-inflammatory drugs are not equally effective in all inflammatory conditions especially in chronic conditions like rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Hence there is a need for newer and safer non steroidal anti-inflammatory drugs directed against cell adhesion molecules are being studied. Objective: Evaluation of Newly Synthesized Benzofuran [3-2, d] Pyrimidine Derivatives for Anti Inflammatory Activity Methods: In the present study some of the newer synthetic compounds like fused benzofuran derivatives, were screened primarily for their anti-inflammatory activity. The results obtained with the newer synthetic compounds were compared with that of standard drug Diclofenac sodium. Results: Leukotrienes thus contribute towards leukocyte emigration. Since the compounds under study were shown to suppress emigration they might be acting by decreasing leukotrienes also. Depending upon these findings the mechanism by which C3 and C1 were acting as anti-inflammatory agents might be summarized as by inhibiting PG release, by inhibiting production of leukotrienes and by suppressing emigration of leucocytes. Conclusion: The efficacy of C3 as anti-inflammatory agent seems to be almost similar to that of diclofenac sodium.


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