• Users Online: 26
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2016  |  Volume : 4  |  Issue : 4  |  Page : 189-193

Comparative study of Griseofulvin versus Terbinafine in treatment of Tinea Corporis patients


1 Assisstant Professor, Department of Pharmacology, Sri Padmavathi Medical College for Women, Tirupati, AP, India
2 Professor, Department of Pharmacology, Malla Reddy Institute of Medical Sciences, Hyderabad, India

Correspondence Address:
Somnath Motgi
Professor, Department of Pharmacology, Malla Reddy Institute of Medical Sciences, Hyderabad
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-7006.302275

Rights and Permissions

Background: Dermatophytosis is a superficial infection of keratinized tissue. It is the most common type of cutaneous fungal infection seen in human beings affecting skin, hair and nails. Tinea corporis is one of the most common clinical forms of dermatophytosis. Objective: To compare two oral antifungal drugs, Griseofulvin and Terbinafine in the treatment of Tinea corporis Methods: This is an open-label, randomized, parallel, comparative study which was carried out in 100. Patients with tinea corporis infection who attended the outpatient Department of Dermatology, Dr. PSIMS & RF, Chinaoutpalli, Krishna (Dist), between October 2009 and Aug 2011. This study was approved by the institutional Ethical Committee of Dr. PSIMS & RF. Written consent was taken from all the patients enrolled in the study. Results: tinea corporis in the present study was more common between 18-45 yrs of age group and it is more common in females. In the Griseofulvin group, I patient showed no clinical improvement, 13 showed partial improvement and 32 patients (69.57%) were completely cured. In the Terbinafine group, 5 patients showed partial improvement and 43 patients (89.58%) were completely cured by the end of 4th week. Conclusion: Terbinafine 250 mg tablet taken once daily for 2 weeks is more effective in complete cure (both clinical and mycological cure) and showed an early clinical response in treatment of tinea corporis compared to Griseofulvin 250 mg tablet taken twice daily for 4 weeks. There was no significant difference between the two drugs regarding tolerability.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed42    
    Printed2    
    Emailed0    
    PDF Downloaded10    
    Comments [Add]    

Recommend this journal