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ORIGINAL ARTICLE
Year : 2017  |  Volume : 5  |  Issue : 4  |  Page : 131-135

Serum ferritin as a guide for chelation therapy in patients of sickle cell anemia


1 Associate Professor, Department of Pediatrics, NKP Salve Institute of Medical Sciences & Lata Mnageshkar Hospital, Nagpur, India
2 Assistant Professor, Department of Pediatrics, NKP Salve Institute of Medical Sciences & Lata Mnageshkar Hospital, Nagpur, India

Correspondence Address:
Anjali Edbor
Associate Professor, Department of Pediatrics, NKP Salve Institute of Medical Sciences & Lata Mnageshkar Hospital, Nagpur
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-7006.302555

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Background: Now-a-days increasing numbers of patients with sickle cell disease (SCD) are receiving blood transfusions. As a result, these patients require treatment with either chelator drugs or exchange transfusion to prevent tissue injury from iron overload. In such cases, serum ferritin (SF) is a noninvasive measure widely used to monitor iron load. Objective: To assess the iron load in patients of SCD by means of serum ferritin levels Methodology: All the patients of SCD proven by Hb electrophoresis presenting to our hospital & consenting for study were evaluated in terms of history, CBC and reticulocyte count. Iron status was measured by means of measuring SF levels. Results: We found that those patients who had severe anemia ( Hb < 5 gm/dl), required more transfusions and hence serum ferritin levels were highly elevated in severely anemic patients as compared with those who had mild anemia ( Hb> 7 gm/dl). The result was found statistically significant (p value - 0.000) in those who required total blood transfusion more than 100 ml/kg/yr. Conclusion: There is increase risk of iron overload in patients of sickle cell anemia who receive chronic blood transfusions for prevention of various sickle cell crises.


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